Reconstructing the thermal Green functions at real times from those at imaginary times

By exploiting the analyticity and boundary value properties of the thermal Green functions that result from the KMS condition in both time and energy complex variables, we treat the general (non-perturbative) problem of recovering the thermal functions at real times from the corresponding functions at imaginary times, introduced as primary objects in the Matsubara formalism. The key property on which we rely is the fact that the Fourier transforms of the retarded and advanced functions in the energy variable have to be the `unique Carlsonian analytic interpolations' of the Fourier coefficients of the imaginary-time correlator, the latter being taken at the discrete Matsubara imaginary energies, respectively in the upper and lower half-planes. Starting from the Fourier coefficients regarded as `data set', we then develop a method based on the Pollaczek polynomials for constructing explicitly their analytic interpolations.Comment: 23 pages, 2 figure

Nature-Inspired Interconnects for Self-Assembled Large-Scale Network-on-Chip Designs

Future nano-scale electronics built up from an Avogadro number of components needs efficient, highly scalable, and robust means of communication in order to be competitive with traditional silicon approaches. In recent years, the Networks-on-Chip (NoC) paradigm emerged as a promising solution to interconnect challenges in silicon-based electronics. Current NoC architectures are either highly regular or fully customized, both of which represent implausible assumptions for emerging bottom-up self-assembled molecular electronics that are generally assumed to have a high degree of irregularity and imperfection. Here, we pragmatically and experimentally investigate important design trade-offs and properties of an irregular, abstract, yet physically plausible 3D small-world interconnect fabric that is inspired by modern network-on-chip paradigms. We vary the framework's key parameters, such as the connectivity, the number of switch nodes, the distribution of long- versus short-range connections, and measure the network's relevant communication characteristics. We further explore the robustness against link failures and the ability and efficiency to solve a simple toy problem, the synchronization task. The results confirm that (1) computation in irregular assemblies is a promising and disruptive computing paradigm for self-assembled nano-scale electronics and (2) that 3D small-world interconnect fabrics with a power-law decaying distribution of shortcut lengths are physically plausible and have major advantages over local 2D and 3D regular topologies

An Integrated Platform for Differential Electrochemical and ISFET Sensing

A fully-integrated differential biosensing platform on CMOS is presented for miniaturized enzyme-based electrochemical sensing. It enables sensor background current elimination and consists of a differential sensor array and a differential readout IC (DiRIC). The sensor array includes a four-electrode sensor for amperometric electrochemical sensing, as well as a differential ISFET-based pH sensor to calibrate the biosensors. The ISFET is biased in weak inversion and co-designed with DiRIC to enable pH measurements from 1 to 14 with resolution of 0.1 pH. DiRIC enables differential current measurement in the range of ¿¿100 ¿¿A with more than 120dB dynamic range

Folates in Trypanosoma brucei: achievements and opportunities

Trypanosoma brucei is the agent of human African trypanosomiasis (HAT), a neglected disease that threatens the lives of 65 million people in sub-Saharan Africa every year. Unfortunately, available therapies are unsatisfactory, due primarily to safety issues and development of drug resistance. Over the last decades significant effort has been made in the discovery of new potential anti-HAT agents, with help from the World Health Organization (WHO) and private\u2013public partnerships such as the Drugs for Neglected Diseases Initiative (DNDi). Whereas antifolates have been a valuable source of drugs against bacterial infections and malaria, compounds effective against T. brucei have not yet been identified. Considering the relatively simple folate metabolic pathway in T. brucei, along with results obtained in this research field so far, we believe that further investigations might lead to effective chemotherapeutic agents. Herein we present a selection of the more promising results obtained so far in this field, underlining the opportunities that could lead to successful therapeutic approaches in the future

Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides

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An explorative study setting a national supportive system of near-miss management for the Italian industrial sector

Initiatives, projects, and programmes for Occupational Safety and Health (OSH) management benefit from supportive systems to develop and properly last over time. National OSH systems were born to enforce the law by applying national regulations. In the last years, most countries have started to take preventative actions to improve workers’ health and safety conditions. Assistance initiatives are growing fast, and new roles and profiles are arising to keep up with changes. Nowadays, national OSH actors usually perform both supervisory and supporting activities. This is widely applied in Italy where several bodies promote and support companies in taking part in OSH initiatives. In Italy, a collaborative project for near-miss management is under development by the Italian National Institute for Insurance against Accidents at Work (INAIL, i.e., in Italian, “Istituto Nazionale Assicurazione Infortuni sul Lavoro”). The project aims at increasing awareness of the relevance of near-miss monitoring. This paper studies the environment setting for this project, so bodies that will have an active role in its implementation and daily management. A focus group with INAIL’s experts and researchers from two Italian universities has enabled to identify key actors and their role in the project’s development and to select the most viable scenarios. This work provides a methodological approach to study other national supportive OSH systems and also detects Italian best practices replicable in other countries

Corrigendum: Effects of a 3-week inpatient multidisciplinary body weight reduction program on body composition and physical capabilities in adolescents and adults with obesity

A correction has been made to Funding. The correct Funding statement is: “Research funded by the Italian Ministry of Health.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated